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Funicular location of ascending axons of lamina I cells in the cat spinal cord A. VANIA APKARIAN, RICHARD 1. STEVENS and CHARLES J. H()DGI-
 

Summary: BRE 21177N
Funicular location of ascending axons of lamina I cells in the cat spinal cord
A. VANIA APKARIAN, RICHARD 1. STEVENS and CHARLES J. H()DGI-
Room 3118. Weiskotten Hall. Upstate Medtcal (_'enter. Syracuse. NY 13210 (I_:..~;,4.
IAcccptcd December llth, 1984,1
Key words: lamina I -- spinal pathways --- dorsolateral funiculus -- spinal cord
The laminar distribution of spinal cord neurons projecting suprasegmentally through different funiculi was determined in the cat us-
ing horseradish peroxidase (HRP) injections combined with selective spinal cord lesions. The lesions were designed to limit the caudal
transport of HRP to either the vcntral funiculi or the dorsolateral funiculus. HRP injections in the ventromedial or ventrolateral funi-
culi resulted in labeling primarily within laminae IV-VIII and a virtual lack of labeling within lamina 1. When the dorsolateral funicu-
lus was injected, 20-25% of all labeled cells were located in lamina I, bilaterally. These results demonstrate that the ascending lamina
I projections are through the dorsolateral funiculus.
Neurons located within lamina 1 of the spinal cord
dorsal horn have been shown, by retrograde trans-
port studies, to project directly to the contralateral
thalamus, together with a smaller projection to the
ipsilateral thalamusS.9.13.2v. Also, physiological stud-
ies have demonstrated that this spinothalamic, lami-
na I projection is nociceptive specificm,2~. Experi-
ments done by Kumazawa et al. 15have indicated that

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine