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Volume 332, number 3, 203-207 FEBS 13088 C 1993 Federation of European Biochemical Societies 0014579?/93/S6.00

Summary: Volume 332, number 3, 203-207 FEBS 13088
C 1993 Federation of European Biochemical Societies 0014579?/93/S6.00
October 1993
Redox control of transcription: sensors, response regulators, activators
and repressors
John F. Allen*
Plant Cell Biology, Lund University, Box 7007, S-220 07 Lund, Sweden
Received 18August 1993
In a growing number of cases, transc~ption of specific genes is known to be governed by oxidation or reduction of electron carriers with which
the gene products interact. The biologicaf function of such control is to activate synthesis of appropriate redox proteins, and to repress synthesis
of inappropriate ones, in response to altered availability of specific electron sources and sinks. In prokaryotic systems this control appears to operate
by two general classes of mechanism: by tw~om~nent relation involving protein phospho~lation on histidine and aspartate; and by direct
oxidation-reduction of gene repressors or activators. For the first class, termed `two~omponent redox regulation', the term `redox sensor' is
proposed for any electron carrier that becomes phospho~lated upon oxidation or reduction and thereby controls phosphorylation of specific
response regulators, while the term `redox response regulator' is proposed for the corresponding sequence-specific DNA-binding protein that
controls transcription as a result of its phospbo~lation by one or more redox sensors. For the second class of redox regulatory mechanism, the
terms `redox activator protein' and `redox repressor protein' are proposed for single proteins intoning both electron transfer and sequence-specific
DNA-binding domains. The structure, function and biological dist~bution of these components are discussed.
Electron transpose Transc~ption~ control; Redox response regulator; Redox sensor; Redox activator protein; Redox repressor protein;
Oxidative stress


Source: Allen, John F. - School of Biological and Chemical Sciences, Queen Mary, University of London


Collections: Renewable Energy; Biology and Medicine