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Digital microfluidics using soft lithography{ John Paul Urbanski,a

Summary: Digital microfluidics using soft lithography{
John Paul Urbanski,a
William Thies,b
Christopher Rhodes,a
Saman Amarasingheb
and Todd Thorsen*a
Received 18th July 2005, Accepted 11th November 2005
First published as an Advance Article on the web 29th November 2005
DOI: 10.1039/b510127a
Although microfluidic chips have demonstrated basic functionality for single applications,
performing varied and complex experiments on a single device is still technically challenging.
While many groups have implemented control software to drive the pumps, valves, and electrodes
used to manipulate fluids in microfluidic devices, a new level of programmability is needed for end
users to orchestrate their own unique experiments on a given device. This paper presents an
approach for programmable and scalable control of discrete fluid samples in a
polydimethylsiloxane (PDMS) microfluidic system using multiphase flows. An immiscible fluid
phase is utilized to separate aqueous samples from one another, and a novel ``microfluidic latch''
is used to precisely align a sample after it has been transported a long distance through the flow
channels. To demonstrate the scalability of the approach, this paper introduces a ``general-
purpose'' microfluidic chip containing a rotary mixer and addressable storage cells. The system is


Source: Amarasinghe, Saman - Computer Science and Artificial Intelligence Laboratory & Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)


Collections: Computer Technologies and Information Sciences