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2001 Macmillan Magazines Ltd brief communications

Summary:  2001 Macmillan Magazines Ltd
brief communications
NATURE CELL BIOLOGY VOL 3 MARCH 2001 http://cellbio.nature.com 297
Distinct roles for G and G in regulating
spindle position and orientation in
Caenorhabditis elegans embryos
Monica Gotta* and Julie Ahringer*
*Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK
e-mail: jaa@mole.bio.cam.ac.uk
Correct placement and orientation of the mitotic spindle is
essential for segregation of localized components and
positioning of daughter cells. Although these processes
are important in many cells, few factors that regulate spin-
dle placement are known. Previous work has shown that
GPB-1, the G subunit of a heterotrimeric G protein, is
required for orientation of early cell division axes in C. ele-
gans embryos. Here we show that GOA-1 (a Go) and the
related GPA-16 are the functionally redundant G subunits
and that GPC-2 is the relevant G subunit that is required
for spindle orientation in the early embryo. We show that


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge


Collections: Biology and Medicine