Summary: Vol. 23 no. 12 2007, pages 1565­1567
BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/btm138
Genetics and population analysis
GENOME: a rapid coalescent-based whole genome simulator
Liming Liang*, Sebastian Zo¨ llner and Gonc¸ alo R. Abecasis
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights,
Ann Arbor, MI 48109, USA
Received and revised on March 14, 2007; accepted on April 3, 2007
Advance Access publication April 25, 2007
Associate Editor: Martin Bishop
ABSTRACT
Summary: GENOME proposes a rapid coalescent-based approach
to simulate whole genome data. In addition to features of standard
coalescent simulators, the program allows for recombination rates
to vary along the genome and for flexible population histories.
Within small regions, we have evaluated samples simulated by
GENOME to verify that GENOME provides the expected LD patterns
and frequency spectra. The program can be used to study the
sampling properties of any statistic for a whole genome study.
Availability: The program and Cþþ source code are available online

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

Collections: Biology and Medicine; Mathematics