Summary: P.6/11NO.867NU OPRS (IRE ACUC)3: 39PMAUG.10.2000
Consent FonD For Reflex Sympathetic Dystrophy Patients
CORTICAL pATHOPHYSIOLOGY OF PAIN
~STIGATOR: Dr. A. VaniaApkarian
SPONSOR: National Institute ofHealth
IntroductionlPurDose: You are being asked to participate in a research study beca~e you have the condition
known as Reflex Sympathetic Dystrophy (RSD), and are over the age of 18. The purpose of this study is to answer
basic questions regarding the organization ofpain in the human brain, as well ~ the biochemistry of the brain.
Your brain activity will be monitored using functional magnetic resonance imaging (~, which makes pictures
of brain activity) during painful stimulation of your hand or foot, or using magnetic resonance spectroscopy (MRS
which makes pictures of brain chemistry) to measure the concentration of different biochemicals in your brain
while you are in your usual pain state. Tho f!vllU study is comprised of tWo sessions. In the first session we check
the characteristics of your pain. In the second session we do brain SCans.The I\1RS study is a single brain scan
Just before tl1ebrain scans you will :fiU out a general medical history, mood and anxiety) depression,
handedness and pain questionnaires. This will take about twenty minutes.
In order to make surethat it is safe for you to h4ve an~ proced~e, you will first be askedto fill out a screening