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Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans
 

Summary: Evolutionary perspectives on innate immunity from the study
of Caenorhabditis elegans
Dennis H Kim and Frederick M Ausubel
Genetic and functional genomic approaches have begun to
define the molecular determinants of pathogen resistance in
Caenorhabditis elegans. Conserved signal transduction
components are required for pathogen resistance, including
a Toll/IL-1 receptor domain adaptor protein that functions
upstream of a conserved p38 MAP kinase pathway. We
suggest that this pathway is an ancestral innate immune
signaling pathway present in the common ancestor of
nematodes, arthropods and vertebrates, which is likely to
predate the involvement of canonical Toll signaling pathways
in innate immunity. We anticipate that the study of pathogen
resistance in C. elegans will continue to provide evolutionary
and mechanistic insights into the signal transduction and
physiology of innate immunity.
Addresses
Department of Genetics, Harvard Medical School, and Department of
Molecular Biology, Massachusetts General Hospital, Boston,

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine