Balanced Amplification: A New Mechanism
of Selective Amplification
of Neural Activity Patterns
Brendan K. Murphy1,2 and Kenneth D. Miller2,*
1Graduate Group in Biophysics, University of California, San Francisco, San Francisco, CA 94122, USA
2Center for Theoretical Neuroscience, Sloan Program in Theoretical Neuroscience, Department of Neuroscience, Columbia University
College of Physicians and Surgeons, New York, NY 10032, USA
In cerebral cortex, ongoing activity absent a stimulus
can resemble stimulus-driven activity in size and
structure. In particular, spontaneous activity in cat
primary visual cortex (V1) has structure significantly
correlated with evoked responses to oriented stimuli.
This suggests that, from unstructured input, cortical
circuits selectively amplify specific activity patterns.
Current understanding of selective amplification