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INFECTION AND IMMUNITY, 0019-9567/00/$04.00 0
 

Summary: INFECTION AND IMMUNITY,
0019-9567/00/$04.00 0
July 2000, p. 41744179 Vol. 68, No. 7
Copyright 2000, American Society for Microbiology. All Rights Reserved.
The Abundant Larval Transcript-1 and -2 Genes of
Brugia malayi Encode Stage-Specific Candidate
Vaccine Antigens for Filariasis
WILLIAM F. GREGORY,1
AGNES K. ATMADJA,2
JUDITH E. ALLEN,1
AND RICK M. MAIZELS1
*
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, United Kingdom,1
and
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia2
Received 22 February 2000/Returned for modification 3 April 2000/Accepted 23 April 2000
Lymphatic filariasis is a major tropical disease caused by the mosquito-borne nematodes Brugia and
Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangi-
tis and elephantiasis. Vaccines against filariasis must generate immunity to the infective mosquito-derived
third-stage larva (L3) without accentuating immunopathogenic responses to lymphatic-dwelling adult para-

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh
Maizels, Rick - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine; Environmental Sciences and Ecology