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Common variants at 30 loci contribute to polygenic dyslipidemia
 

Summary: Common variants at 30 loci contribute to polygenic
dyslipidemia
Sekar Kathiresan*1­5,37,38, Cristen J Willer6,37, Gina M Peloso4,7,37, Serkalem Demissie4,7,37, Kiran Musunuru1,2,
Eric E Schadt8, Lee Kaplan9, Derrick Bennett10, Yun Li6, Toshiko Tanaka11, Benjamin F Voight2,3,12,
Lori L Bonnycastle13, Anne U Jackson6, Gabriel Crawford3, Aarti Surti3, Candace Guiducci3, Noel P Burtt3,
Sarah Parish10, Robert Clarke10, Diana Zelenika14, Kari A Kubalanza13, Mario A Morken13, Laura J Scott6,
Heather M Stringham6, Pilar Galan15, Amy J Swift13, Johanna Kuusisto16, Richard N Bergman17,
Jouko Sundvall18, Markku Laakso16, Luigi Ferrucci11, Paul Scheet6, Serena Sanna19, Manuela Uda19,
Qiong Yang4,7, Kathryn L Lunetta4,7, Jose´e Dupuis4,7, Paul I W de Bakker20, Christopher J O'Donnell4,21,
John C Chambers22, Jaspal S Kooner23, Serge Hercberg15, Pierre Meneton24, Edward G Lakatta25,
Angelo Scuteri26, David Schlessinger27, Jaakko Tuomilehto18, Francis S Collins13, Leif Groop28,29,
David Altshuler3,5,12,30, Rory Collins10, G Mark Lathrop14, Olle Melander31, Veikko Salomaa33,
Leena Peltonen3,32,34, Marju Orho-Melander28, Jose M Ordovas35,38, Michael Boehnke6,38,
Gonc¸alo R Abecasis6,38, Karen L Mohlke36,38 & L Adrienne Cupples4,7,38
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors
for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840
individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations
(each with P o 5 Â 10À8), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci
include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near
ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics