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INFECTION AND IMMUNITY, May 2008, p. 21772182 Vol. 76, No. 5 0019-9567/08/$08.00 0 doi:10.1128/IAI.00647-07
 

Summary: INFECTION AND IMMUNITY, May 2008, p. 21772182 Vol. 76, No. 5
0019-9567/08/$08.00 0 doi:10.1128/IAI.00647-07
Copyright 2008, American Society for Microbiology. All Rights Reserved.
Anamnestic Protective Immunity to Bacillus anthracis Is Antibody
Mediated but Independent of Complement and Fc Receptors
Eric T. Harvill,1
Manuel Osorio,2
Crystal L. Loving,2
Gloria M. Lee,2
Vanessa K. Kelly,2
and Tod J. Merkel2
*
Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park,
Pennsylvania 16802,1
and Center for Biologics Evaluation and Research, U.S. Food and Drug Administration,
8800 Rockville Pike, Bethesda, Maryland 208922
Received 9 May 2007/Returned for modification 14 September 2007/Accepted 15 February 2008
The threat of bioterrorist use of Bacillus anthracis has focused urgent attention on the efficacy and mecha-
nisms of protective immunity induced by available vaccines. However, the mechanisms of infection-induced
immunity have been less well studied and defined. We used a combination of complement depletion along with

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine