Summary: invited review
Structural determinants of glomerular permeability
WILLIAM M. DEEN,1,2
MATTHEW J. LAZZARA,1
AND BRYAN D. MYERS3
1
Department of Chemical Engineering and 2
Division of Bioengineering and Environmental
Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; and
3
Nephrology Division, Stanford University Medical Center, Stanford, California 94305
Deen, William M., Matthew J. Lazzara, and Bryan D. Myers.
Structural determinants of glomerular permeability. Am J Physiol Renal
Physiol 281: F579­F596, 2001.--Recent progress in relating the func-
tional properties of the glomerular capillary wall to its unique structure
is reviewed. The fenestrated endothelium, glomerular basement mem-
brane (GBM), and epithelial filtration slits form a series arrangement in
which the flow diverges as it enters the GBM from the fenestrae and
converges again at the filtration slits. A hydrodynamic model that com-
bines morphometric findings with water flow data in isolated GBM has

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

Collections: Biology and Medicine