Summary: CUTTING EDGE
IMMUNOLOGY
THE
OF
JOURNAL
Cutting Edge: Innate Immune System Discriminates
between RNA Containing Bacterial versus Eukaryotic
Structural Features That Prime for High-Level IL-12
Secretion by Dendritic Cells1
Gary K. Koski,2
* Katalin Kariko´,
Shuwen Xu,* Drew Weissman,
Peter A. Cohen,§
and
Brian J. Czerniecki*
RNA derived from bacterial but not eukaryotic sources,
when transfected into human monocyte-derived dendritic
cell precursors, induces high-level IL-12 secretion in con-
junction with dendritic cell maturation stimuli. In vitro-
transcribed mRNA that mimics the structure of bacterial

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

Collections: Biotechnology