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Electrical Microstimulation Distinguishes Distinct Saccade-Related Areas in the Posterior Parietal Cortex

Summary: Electrical Microstimulation Distinguishes Distinct Saccade-Related
Areas in the Posterior Parietal Cortex
Neurologische Universita¨tsklinik, Sektion fu¨r Visuelle Sensomotorik, 72076 Tu¨bingen, Germany; and 2
Institute of Technology, Cambridge, Massachusetts 02139
Thier, Peter and Richard A. Andersen. Electrical microstimula- area LIP and neighboring parts of the posterior parietal cor-
tion distinguishes distinct saccade-related areas in the posterior tex is their consistent modulation by eye position (Andersen
parietal cortex. J. Neurophysiol. 80: 1713­1735, 1998. Electrical et al. 1990b). This finding has been instrumental for the
microstimulation (0.1-ms bipolar pulses at 500 Hz, current strength development of the view that these areas encode goals for
usually between 100 and 200 mA) was used to delineate saccade-
saccades in head-centered coordinates, engraved in the col-related areas in the posterior parietal cortex of monkeys. Stimula-
lective activity of assemblies of saccade-related cells spreadtion-induced saccades were found to be restricted to the lateral
out over larger parts of these regions (Zipser and Andersenintraparietal area (area LIP) in the intraparietal sulcus (IPS) and
1988). This view is incompatible with the conclusions de-a region on the medial aspect of the parietal lobe (area MP, medial
parietal area), close to the caudal end of the cingulate sulcus, duced from previous electrical microstimulation studies of
whereas stimulation of area 7a did not evoke eye movements. Two the posterior parietal cortex by Shibutani and co-workers
different types of evoked saccades were observed. Modified vector (1984) and Kurylo and Skavenski (1991). These authors


Source: Andersen, Richard - Division of Biology, California Institute of Technology


Collections: Biology and Medicine