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Endocr. Rev. 2010 31:343-363 originally published online Feb 17, 2010; , doi: 10.1210/er.2009-0035 Oliver C. Richards, Summer M. Raines and Alan D. Attie
 

Summary: Endocr. Rev. 2010 31:343-363 originally published online Feb 17, 2010; , doi: 10.1210/er.2009-0035
Oliver C. Richards, Summer M. Raines and Alan D. Attie
Secretion and Peripheral Insulin Action
The Role of Blood Vessels, Endothelial Cells, and Vascular Pericytes in Insulin
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Copyright The Endocrine Society. All rights reserved. Print ISSN: 0021-972X. Online
The Role of Blood Vessels, Endothelial Cells, and
Vascular Pericytes in Insulin Secretion and Peripheral
Insulin Action
Oliver C. Richards, Summer M. Raines, and Alan D. Attie
Department of Biochemistry (O.C.R., S.M.R., A.D.A.) and Graduate Program in Cellular and Molecular Biology (O.C.R.,
A.D.A.), University of Wisconsin-Madison, Madison, Wisconsin 53706
The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin must efficiently
enter the bloodstream from pancreatic -cells, circulate throughout the body, and efficiently exit the
bloodstream to reach target tissues and mediate its effects. Defects in the vasculature of pancreatic islets
can lead to diabetic phenotypes. Similarly, insulin resistance is accompanied by defects in the vasculature
of skeletal muscle, which ultimately reduce the ability of insulin and nutrients to reach myocytes. An
underappreciated participant in these processes is the vascular pericyte. Pericytes, the smooth muscle-like
cells lining the outsides of blood vessels throughout the body, have not been directly implicated in insulin

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

 

Collections: Biology and Medicine