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REVIEW Open Access Bioresponsive matrices in drug delivery

Summary: REVIEW Open Access
Bioresponsive matrices in drug delivery
Jin-Oh You, Dariela Almeda, George JC Ye, Debra T Auguste*
For years, the field of drug delivery has focused on (1) controlling the release of a therapeutic and (2) targeting the
therapeutic to a specific cell type. These research endeavors have concentrated mainly on the development of
new degradable polymers and molecule-labeled drug delivery vehicles. Recent interest in biomaterials that respond
to their environment have opened new methods to trigger the release of drugs and localize the therapeutic within
a particular site. These novel biomaterials, usually termed "smart" or "intelligent", are able to deliver a therapeutic
agent based on either environmental cues or a remote stimulus. Stimuli-responsive materials could potentially elicit
a therapeutically effective dose without adverse side effects. Polymers responding to different stimuli, such as pH,
light, temperature, ultrasound, magnetism, or biomolecules have been investigated as potential drug delivery vehi-
cles. This review describes the most recent advances in "smart" drug delivery systems that respond to one or multi-
ple stimuli.
Polymeric materials that respond to a stimulus are often
called "smart" or "intelligent" due to their intrinsic ability
to alter their physical or chemical properties. For the
majority of the polymers that fall into this category, the
response to a change in the surrounding environment is


Source: Auguste, Debra T. - School of Engineering and Applied Sciences, Harvard University


Collections: Materials Science; Biology and Medicine