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Summary: BioMed Central
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(page number not for citation purposes)
Molecular Pain
Open AccessResearch
A preliminary fMRI study of analgesic treatment in chronic back
pain and knee osteoarthritis
Marwan N Baliki1, Paul Y Geha1, Rami Jabakhanji1, Norm Harden2,
Thomas J Schnitzer and A Vania Apkarian*1,3
Address: 1Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL, 60611, USA,
2Rehabilitation Institute of Chicago, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL, 60611, USA and
3Departments of Anesthesia, Surgery, and Lurie Cancer Center, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave,
Chicago IL, 60611, USA
Email: Marwan N Baliki - m-baliki@northwestern.edu; Paul Y Geha - p-geha@northwestern.edu; Rami Jabakhanji - r.jabakhanji@gmail.com;
Norm Harden - nharden@ric.org; Thomas J Schnitzer - tjs@northwestern.edu; A Vania Apkarian* - a-apkarian@northwestern.edu
* Corresponding author
Abstract
The effects of an analgesic treatment (lidocaine patches) on brain activity in chronic low back pain
(CBP) and in knee osteoarthritis (OA) were investigated using serial fMRI (contrasting fMRI
between before and after two weeks of treatment). Prior to treatment brain activity was distinct
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