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Proc. Natl. Acad. Sci. USA Vol. 96, pp. 67456750, June 1999
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 96, pp. 67456750, June 1999
Cell Biology
Broad patterns of gene expression revealed by clustering analysis
of tumor and normal colon tissues probed by
oligonucleotide arrays
U. ALON*, N. BARKAI*, D. A. NOTTERMAN*, K. GISH, S. YBARRA, D. MACK, AND A. J. LEVINE*
Departments of *Molecular Biology and Physics, Princeton University, Princeton, NJ 08540; and EOS Biotechnology, 225A Gateway Boulevard,
South San Francisco, CA 94080
Contributed by A. J. Levine, April 13, 1999
ABSTRACT Oligonucleotide arrays can provide a broad
picture of the state of the cell, by monitoring the expression
level of thousands of genes at the same time. It is of interest
to develop techniques for extracting useful information from
the resulting data sets. Here we report the application of a
two-way clustering method for analyzing a data set consisting
of the expression patterns of different cell types. Gene expres-
sion in 40 tumor and 22 normal colon tissue samples was
analyzed with an Affymetrix oligonucleotide array comple-
mentary to more than 6,500 human genes. An efficient two-

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine