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Copyright 1999 by the Genetics Society of America Unusual Haplotype Structure at the Proximal Breakpoint of In(2L)t in a Natural
 

Summary: Copyright 1999 by the Genetics Society of America
Unusual Haplotype Structure at the Proximal Breakpoint of In(2L)t in a Natural
Population of Drosophila melanogaster
Peter Andolfatto,* Jeffrey D. Wall
and Martin Kreitman*,
*Committee on Genetics and
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637
Manuscript received September 23, 1998
Accepted for publication July 9, 1999
ABSTRACT
The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila
melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected
nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its
evolutionary history. The finding of a novel LINE-like element near the In(2L)t breakpoint junction in
sampled inverted chromosomes supports a transposable element-mediated origin for this inversion. An
analysis of nucleotide variation in a Costa Rican population sample of standard and inverted chromosomes
indicates a unique and relatively recent origin for In(2L)t. Additional In(2L)t alleles from three geographi-
cally diverse populations reveal no detectable geographic differentiation. Low levels of In(2L)t nucleotide
polymorphism suggest a recent increase in the inversion's frequency in tropical populations. An unusual
feature of our sample of standard alleles is a marked heterogeneity in levels of linkage disequilibrium

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine