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Summary: Global Gene Expression Analysis Reveals Evidence for
Decreased Lipid Biosynthesis and Increased Innate
Immunity in Uninvolved Psoriatic Skin
Johann E. Gudjonsson1,6
, Jun Ding2,6
, Xing Li3
, Rajan P. Nair1
, Trilokraj Tejasvi1
, Zhaohui S. Qin2
,
Debashis Ghosh4
, Abhishek Aphale1
, Deborah L. Gumucio3
, John J. Voorhees1
, Goncalo R. Abecasis2
and James T. Elder1,5
Psoriasis is a genetically determined inflammatory skin disease. Although the transition from uninvolved into
lesional skin is accompanied by changes in the expression of multiple genes, much less is known about the
difference between uninvolved skin from psoriatic patients as opposed to skin from normal individuals.
Multiple biochemical and morphological changes were reported decades ago in uninvolved psoriatic skin but
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