Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Neuronal and Astroglial Responses to the Serotonin and Norepinephrine Neurotoxin: 1-Methyl-4-(2 -aminophenyl)-
 

Summary: Neuronal and Astroglial Responses to the Serotonin and
Norepinephrine Neurotoxin: 1-Methyl-4-(2 -aminophenyl)-
1,2,3,6-tetrahydropyridine
BETH A. LUELLEN, DIANE B. MILLER, ANGELA C. CHISNELL, DENNIS L. MURPHY, JAMES P. O'CALLAGHAN, and
ANNE MILASINCIC ANDREWS
Department of Chemistry and Huck Institute for Life Sciences, The Pennsylvania State University, University Park, Pennsylvania (B.A.L., A.C.C.,
A.M.A.); Laboratory of Neurotoxicology, Centers for Disease Control and Prevention/National Institute of Environmental Health Sciences,
Morgantown, West Virginia (D.B.M., J.P.O.); and Laboratory of Clinical Science, National Institutes of Mental Health, Bethesda, Maryland
(D.L.M.)
Received June 17, 2003; accepted September 12, 2003
ABSTRACT
1-Methyl-4-(2 -aminophenyl)-1,2,3,6-tetrahydropyridine (2 -NH2-
MPTP) causes long-term loss of forebrain serotonin (5-HT) and
norepinephrine (NE) and consequently, is unlike 1-methyl-4-phe-
nyl-1,2,3,6-tetrahydropyridine (MPTP) and its other 2 -analogs
that primarily deplete striatal dopamine (DA). In the present inves-
tigation into the acute effects of 2 -NH2-MPTP in mice, profound
decreases in cortical and hippocampal 5-HT and NE to 10 to 40%
of control were observed as early as 30 min post-treatment and
lasted throughout the ensuing 21 days. Striatal DA was decreased

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine