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Summary: Parsing the role of dopamine in human
reward and its cognitive consequences
using genetic imaging
Esther Aarts, Ardi Roelofs, Barbara Franke, Mark Rijpkema, Guillen Fernandez, Rick Helmich, & Roshan Cools
Introduction
Dopamine has been hypothesized to provide the basis for the interaction
between motivation and cognition. However, there is no evidence for this
hypothesis in humans. In the present genetic imaging study, we sought to
determine the role of dopamine in the component processes of
reward, and its consequences for cognitive flexibility.
Experimental Paradigm
We employed a task-switch design with reward cues preceding each trial
and feedback following each manual response (Fig. 1).
Contrasts of interest:
- high > low reward during reward cues
- high > low reward during task cues
- switch > repeat targets
- positive > negative feedback
Genotyping
- took into account inter-individual variation in the dopamine transporter
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