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Summary: Cell, Vol. 116, 661670, March 5, 2004, Copyright 2004 by Cell Press
Complement-Like Protein TEP1
Is a Determinant of Vectorial Capacity
in the Malaria Vector Anopheles gambiae
Within the insect midgut, Plasmodium gametocytes are
rapidly activated to produce gametes. Fertilization leads
to the formation of zygotes which, 1620 hr later, trans-
form into motile ookinetes. Approximately 24 hr after an
infectious bloodmeal, the ookinetes invade and cross
Stephanie Blandin,1
Shin-Hong Shiao,2
Luis F. Moita,1,4
Chris J. Janse,3
Andrew P. Waters,3
Fotis C. Kafatos,1
and Elena A. Levashina1,2,
*
1
European Molecular Biology Laboratory
Meyerhofstrasse 1
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