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A Simple Measure of the Dynamics of Segmented Genomes: An Application to
 

Summary: A Simple Measure of the Dynamics of
Segmented Genomes: An Application to
Influenza
St´ephane Aris-Brosou1,2
1
Department of Biology and Center for Advanced Research in Environmental
Genomics, University of Ottawa, Ottawa, ON K1N 6N5, Canada
2
Department of Mathematics and Statistics, University of Ottawa
sarisbro@uottawa.ca
Abstract. The severity of influenza epidemics, which can potentially
become a pandemic, has been very difficult to predict. However, past ef-
forts were focusing on gene-by-gene approaches, while it is acknowledged
that the whole genome dynamics contribute to the severity of an epi-
demic. Here, putting this rationale into action, I describe a simple mea-
sure of the amount of reassortment that affects influenza at a genomic
scale during a particular year. The analysis of 530 complete genomes of
the H1N1 subtype, sampled over eleven years, shows that the proposed
measure explains 58% of the variance in the prevalence of H1 influenza in
the US population. The proposed measure, denoted nRF, could therefore

  

Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa

 

Collections: Biology and Medicine