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Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians
 

Summary: Colloquium
Ingestion of bacterially expressed double-stranded
RNA inhibits gene expression in planarians
Phillip A. Newmark*
, Peter W. Reddien
, Francesc Cebria`*, and Alejandro Sa´nchez Alvarado
*Department of Cell and Structural Biology, University of Illinois at Urbana­Champaign, B107 Chemical Life Sciences Laboratory, 601 South Goodwin
Avenue, Urbana, IL 61801; and Department of Neurobiology and Anatomy, University of Utah School of Medicine, 401 Medical Research and
Education Building, 20 North 1900 East, Salt Lake City, UT 84132
Freshwater planarian flatworms are capable of regenerating com-
plete organisms from tiny fragments of their bodies; the basis for
this regenerative prowess is an experimentally accessible stem cell
population that is present in the adult planarian. The study of these
organisms, classic experimental models for investigating metazoan
regeneration, has been revitalized by the application of modern
molecular biological approaches. The identification of thousands
of unique planarian ESTs, coupled with large-scale whole-mount in
situ hybridization screens, and the ability to inhibit planarian gene
expression through double-stranded RNA-mediated genetic inter-
ference, provide a wealth of tools for studying the molecular

  

Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah

 

Collections: Biology and Medicine