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Annu. Rev. Microbiol. 2002. 56:13965 doi: 10.1146/annurev.micro.56.012302.160907
 

Summary: Annu. Rev. Microbiol. 2002. 56:13965
doi: 10.1146/annurev.micro.56.012302.160907
Copyright c 2002 by Annual Reviews. All rights reserved
First published online as a Review in Advance on May 16, 2002
EVOLUTION OF DRUG RESISTANCE IN
CANDIDA ALBICANS
Leah E. Cowen, James B. Anderson, and
Linda M. Kohn
Department of Botany, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada;
e-mail: lcowen@utm.utoronto.ca; janderso@utm.utoronto.ca; kohn@utm.utoronto.ca
Key Words genomics, experimental evolution, Saccharomyces cerevisiae, HIV,
adaptation
s Abstract The widespread deployment of antimicrobial agents in medicine and
agriculture is nearly always followed by the evolution of resistance to these agents
in the pathogen. With the limited availability of antifungal drugs and the increasing
incidence of opportunistic fungal infections, the emergence of drug resistance in fun-
gal pathogens poses a serious public health concern. Antifungal drug resistance has
been studied most extensively with the yeast Candida albicans owing to its impor-
tance as an opportunistic pathogen and its experimental tractability relative to other
medically important fungal pathogens. The emergence of antifungal drug resistance

  

Source: Anderson, James B. - Department of Ecology and Evolutionary Biology, University of Toronto
Kohn, Linda M. - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collections: Biology and Medicine; Environmental Sciences and Ecology