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Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by
 

Summary: Major loci influencing serum triglyceride levels
on 2q14 and 9p21 localized by
homozygosity-by-descent mapping in a large
Hutterite pedigree
Dina L. Newman1,*, Mark Abney1,2
, Harvey Dytch1
, Rodney Parry3
,
Mary Sara McPeek1,2
and Carole Ober1
1
Department of Human Genetics and 2
Department of Statistics, University of Chicago, Chicago, IL 60637, USA and
3
School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
Received September 10, 2002; Revised and Accepted October 31, 2002
Serum triglyceride (TG) level is a well-known risk factor for cardiovascular disease, a leading cause of
morbidity and mortality in Western countries. Although genome-wide scans for TG have been conducted in
several populations, few loci have shown strong evidence for linkage. The Hutterites are a founder
population, which practices a communal lifestyle that includes a uniformly high-fat, high-cholesterol diet. We

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago

 

Collections: Computer Technologies and Information Sciences; Biology and Medicine