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Attenuated sensitivity to neuroactive steroids in -aminobutyrate type A receptor delta subunit

Summary: Attenuated sensitivity to neuroactive steroids in
-aminobutyrate type A receptor delta subunit
knockout mice
Robert M. Mihaleka, Pradeep K. Banerjeeb, Esa R. Korpic, Joseph J. Quinlana, Leonard L. Firestonea, Zhi-Ping Mid, Carl Lagenaurd,
Verena Trettere, Werner Siegharte, Stephan G. Anagnostarasf, Jennifer R. Sagef, Michael S. Fanselowf, Alessandro Guidottig,
Igor Spigelmanh, Zhiwei Lib,h, Timothy M. DeLoreyj, Richard W. Olsenb,k, and Gregg E. Homanicsa,i,l
Departments of aAnesthesiology Critical Care Medicine, iPharmacology, and dNeurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
15261; jMolecular Research Institute, 2495 Old Middlefield Way, Mountain View, CA 94043; cDepartment of Pharmacology and Clinical Pharmacology,
University of Turku, FIN-20520 Turku, Finland; eUniversity Clinic for Psychiatry, Section of Biochemical Psychiatry, Wa¨hringer Gu¨ rtel 18­20, A-1090 Vienna,
Austria; fDepartment of Psychology, University of California, Los Angeles, CA 90095-1563; gPsychiatric Institute, Department of Psychiatry, University of
Illinois, Chicago, IL 60612; hDivision of Oral Biology and Medicine, University of California School of Dentistry and Departments of bMolecular and Medical
Pharmacology and kAnesthesiology, University of California School of Medicine, Los Angeles, CA 90095
Edited by Erminio Costa, University of Illinois, Chicago, IL, and approved September 8, 1999 (received for review July 21, 1999)
-Aminobutyric acid (GABA) type A receptors mediate fast inhib-
itory synaptic transmission and have been implicated in responses
to sedative hypnotic agents (including neuroactive steroids), anx-
iety, and learning and memory. Using gene targeting technology,
we generated a strain of mice deficient in the subunit of the
GABA type A receptors. In vivo testing of various behavioral
responses revealed a strikingly selective attenuation of responses


Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego


Collections: Biology and Medicine