Summary: Ionotropic Amino-acid Receptors
BIOS 586 ­ Cellular and Molecular neurobiology
Deebika Balu
13 Feb 2012
· Both non-NMDA and
NMDAR are cation selective.
· Non-NMDAR (AMPA/
Kainate) regulate a channel
permeable to Na and K ions
· NMDA allows Ca currents
along with Na and K currents
· Most AMPARs and NMDAR
are heterotetrameric = dimer
of dimers
AMPA ­ (GluR2+ GluR1,3 or 4)
NMDA ­ (NR1 + NR2)
Excitatory AA receptors
(Glutamate)
· Most GABAA receptors are
believed to be composed of ,

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

Collections: Biology and Medicine