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Trim: 247mm 174mm Top: 12.653mm Gutter: 16.871mm CUUK1505-10 CUUK1505/Seth ISBN: 978 1 107 00049 0 June 23, 2011 11:19
 

Summary: Trim: 247mm 174mm Top: 12.653mm Gutter: 16.871mm
CUUK1505-10 CUUK1505/Seth ISBN: 978 1 107 00049 0 June 23, 2011 11:19
10 Action selection and refinement in
subcortical loops through basal
ganglia and cerebellum
James C. Houk
Summary
Subcortical loops through the basal ganglia and cerebellum form computationally pow-
erful distributed processing modules (DPMs). This chapter relates the computational
features of a DPM's loop through the basal ganglia to experimental results for two kinds
of natural action selection. First, data from both monkeys and humans in a step-tracking
task were used to decipher the neural mechanisms that underlie the detection of move-
ment errors leading to selection of corrective movements called submovements. Second,
functional brain imaging of human subjects during a serial-order recall task was used
to study brain activity associated with decoding a sequence of actions from informa-
tion held in working memory. Our DPM-based model assists in the interpretation of
puzzling data from both of these experiments. These analyses lead to a broad discus-
sion of the DPM concept and how it relates to neuroscience, modularity, engineering,
evolution, mathematical recursion, agent-based modelling, Bayesian computations, and
brain disorders. The loops through basal ganglia and cerebellum profit from exceptional

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine