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Cell-Type Specific Organization of Glycine Receptor Clusters in the
 

Summary: Cell-Type Specific Organization of
Glycine Receptor Clusters in the
Mammalian Spinal Cord
FRANCISCO J. ALVAREZ,* DIANNE E. DEWEY, DEBORAH A. HARRINGTON,
AND ROBERT E.W. FYFFE
Department of Anatomy, Wright State University, Dayton, Ohio 45435
ABSTRACT
Glycinergic synapses play a major role in shaping the activity of spinal cord neurons. The
spatial organization of postsynaptic receptors is likely to determine many functional
parameters at these synapses and is probably related to the integrative capabilities of
different neurons. In the present study, we have investigated the organization of gephyrin
expression along the dendritic membranes of - and -motoneurons, Ia inhibitory interneu-
rons, and Renshaw cells. Gephyrin is a protein responsible for the postsynaptic clustering of
glycine receptors, and the features of gephyrin and glycine receptor 1-subunit immunofluores-
cent clusters displayed similar characteristics on ventral horn spinal neurons. However, the
density of clusters and their topographical organization and architecture varied widely in
different neurons and in different dendritic regions. For motoneurons and Ia inhibitory
interneurons, cluster size and complexity increased with distance from the soma, perhaps as a
mechanism to enhance the influence of distal synapses. Renshaw cells were special in that
they displayed an abundant complement of large and morphologically complex clusters

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collections: Biology and Medicine