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number of new techniques for tracing and cataloging brains, beginning in
 

Summary: number of new techniques for tracing
and cataloging brains, beginning in
smaller animals with smaller brains as
a precursor to the first human map.
Because the diameter of the finest wires
and synaptic connections requires elec-
tron imaging to resolve, we have auto-
mated the previously labor intensive
process of brain sectioning and subse-
quent imaging by an electron micro-
scope. The approach we settled on uses
a novel microtome to turn the large
volume of brain into a linear continuous
strip of very thin tape (a process not
unlike paring an apple). This tape is
then automatically imaged in a scanning
electron microscope with enough resol-
ving ability to trace the smallest neuro-
nal processes (Kasthuri et al, 2009). To
trace the longer pathways that inter-

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine