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Behavioral/Systems/Cognitive Intracranial EEG Reveals a Time-and Frequency-Specific
 

Summary: Behavioral/Systems/Cognitive
Intracranial EEG Reveals a Time- and Frequency-Specific
Role for the Right Inferior Frontal Gyrus and Primary Motor
Cortex in Stopping Initiated Responses
Nicole Swann,1,2 Nitin Tandon,3 Ryan Canolty,4 Timothy M. Ellmore,3 Linda K. McEvoy,5 Stephen Dreyer,3
Michael DiSano,3 and Adam R. Aron1,2
1Neuroscience Program, University of California, San Diego, La Jolla, California 92093-0662, 2Department of Psychology, University of California, San
Diego, La Jolla, California 92093-0109, 3Department of Neurosurgery, University of Texas Medical School at Houston, Houston, Texas 77030, 4Helen Wills
Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720-3192 and Department of Electrical Engineering and Computer
Sciences, University of California, Berkeley, California 94720-1770, and 5Department of Radiology, University of California, San Diego, San Diego,
California 92103-8756
Inappropriateresponsetendenciesmaybestoppedviaaspecificfronto/basalganglia/primarymotorcorticalnetwork.Wesoughttocharacter-
izethefunctionalroleoftworegionsinthisputativestoppingnetwork,therightinferiorfrontalgyrus(IFG)andtheprimarymotorcortex(M1),
usingelectocorticographyfromsubduralelectrodesinfourpatientswhiletheyperformedastop-signaltask.Oneachtrial,amotorresponsewas
initiated,andonaminorityoftrialsastopsignalinstructedthepatienttotrytostoptheresponse.Foreachpatient,therewasagreaterrightIFG
response in the beta frequency band ( 16 Hz) for successful versus unsuccessful stop trials. This finding adds to evidence for a functional
network for stopping because changes in beta frequency activity have also been observed in the basal ganglia in association with behavioral
stopping.Inaddition,therightIFGresponseoccurred100250msafterthestopsignal,atimerangeconsistentwithaputativeinhibitorycontrol
processratherthanwithstop-signalprocessingorfeedbackregardingsuccess.AdownstreamtargetofinhibitorycontrolisM1.Ineachpatient,
therewasalpha/betabanddesynchronizationinM1forstoptrials.However,thedegreeofdesynchronizationinM1waslessforsuccessfullythan

  

Source: Aron, Adam - Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine