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The Uroepithelium: Not Just a Passive Barrier Gerard Apodaca
 

Summary: Review
The Uroepithelium: Not Just a Passive Barrier
Gerard Apodaca
Renal-Electrolyte Division of the Department of Medicine,
Laboratory of Epithelial Cell Biology, and Department of
Cell Biology and Physiology, University of Pittsburgh,
Pittsburgh, PA 15261, USA, gla6@pitt.edu
The uroepithelium lines the inner surface of the renal
pelvis, the ureters, and the urinary bladder, where it
forms a tight barrier that allows for retention of urine,
while preventing the unregulated movement of ions,
solutes, and toxic metabolites across the epithelial bar-
rier. In the case of the bladder, the permeability barrier
must be maintained even as the organ undergoes cyclical
changes in pressure as it fills and empties. Beyond
furthering our understanding of barrier function, new
analysis of the uroepithelium is providing information
about how detergent-insoluble membrane/protein
domains called plaques are formed at the apical plasma
membrane of the surface umbrella cells, how mechanical

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine