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Nature GeNetics VOLUME 42 | NUMBER 5 | MAY 2010 373 b r i e f c o m m u n i c at i o n s
 

Summary: Nature GeNetics VOLUME 42 | NUMBER 5 | MAY 2010 373
b r i e f c o m m u n i c at i o n s
Usinggenome-wideassociation,weidentifycommonvariants
at2p12p13,6q26,17q23and19q13associatedwith
serumcreatinine,amarkerofkidneyfunction(P=10-10to
10-15).Ofthese,rs10206899(nearNAT8,2p12p13)and
rs4805834(nearSLC7A9,19q13)werealsoassociatedwith
chronickidneydisease(P=5.010-5andP=3.610-4,
respectively).Ourfindingsprovideinsightintometabolic,
soluteanddrug-transportpathwaysunderlyingsusceptibility
tochronickidneydisease.
InNorthAmericaandEurope,chronickidneydisease(CKD)affects~11%
of adults. CKD is associated with high morbidity and, in the advanced
stage,requireslife-supporttreatmentbyrenaldialysisortransplantation1.
CKD is also a major risk factor for myocardial infarction and stroke.
CKD is a multifactorial disorder with an important genetic compo-
nent2. A number of monogenic disorders underlying CKD have been
identified, though these account for only a small proportion of the
total burden of kidney disease. Recent studies have identified common
variants at the UMOD, SHROOM3, GATM and MYH9 loci that are

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics