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Summary: A Xenopus tropicalis oligonucleotide microarray works
across species using RNA from Xenopus laevis
Andrew D. Chalmersa,b,*, Kim Goldstonea,b
, James C. Smitha,c
, Mike Gilchrista
,
Enrique Amayaa,c
, Nancy Papalopulua,b,*
a
Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, CB2 1QR, Cambridge, UK
b
Department of Anatomy, University of Cambridge, Cambridge, UK
c
Department of Zoology, University of Cambridge, Cambridge, UK
Received 24 September 2004; accepted 27 September 2004
Available online 26 October 2004
Abstract
Microarrays have great potential for the study of developmental biology. As a model system Xenopus is well suited for making the most of
this potential. However, Xenopus laevis has undergone a genome wide duplication meaning that most genes are represented by two
paralogues. This causes a number of problems. Most importantly the presence of duplicated genes mean that a X. laevis microarray will have
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