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Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types

Summary: Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3
complex in diverse cell types
David P. Welchman a
, Laura D. Mathies b
, Julie Ahringer a,
The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, CB2 1QN, UK
Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA
Received for publication 5 February 2007; accepted 14 February 2007
Available online 21 February 2007
During animal development, a complex of Par3, Par6 and atypical protein kinase C (aPKC) plays a central role in cell polarisation. The small G
protein Cdc42 also functions in cell polarity and has been shown in some cases to act by regulating the Par3 complex. However, it is not yet
known whether Cdc42 and the Par3 complex widely function together in development or whether they have independent functions. For example,
many studies have implicated Cdc42 in cell migrations, but the Par3 complex has only been little studied, with conflicting results. Here we
examine the requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in a range of different developmental events. We found similar
requirements in all tissues examined, including polarised growth of vulval precursors and seam cells, migrations of neuroblasts and axons, and the
development of the somatic gonad. We also propose a novel role for primordial germ cells in mediating coalescence of the Caenorhabditis elegans
gonad. These results indicate that CDC-42 and the PAR-3/PAR-6/aPKC complex function together in diverse cell types.


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge


Collections: Biology and Medicine