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Limited Lifespan of Fragile Regions in Mammalian Evolution
 

Summary: Limited Lifespan of Fragile Regions in
Mammalian Evolution
Max A. Alekseyev1
and Pavel A. Pevzner2
1
University of South Carolina, Columbia, SC, U.S.A.
2
University of California, San Diego, CA, U.S.A.
Abstract. An important question in genome evolution is whether there
exist fragile regions (rearrangement hotspots) where chromosomal rear-
rangements are happening over and over again. Although nearly all re-
cent studies supported the existence of fragile regions in mammalian
genomes, the most comprehensive phylogenomic study of mammals (Ma
et al. (2006) Genome Research 16, 1557-1565) raised some doubts about
their existence. We demonstrate that fragile regions are subject to a
"birth and death" process, implying that fragility has limited evolution-
ary lifespan. This finding implies that fragile regions migrate to different
locations in different mammals, explaining why there exist only a few
chromosomal breakpoints shared between different lineages. The birth
and death of fragile regions phenomenon reinforces the hypothesis that

  

Source: Alekseyev, Max - Department of Computer Science and Engineering, University of South Carolina

 

Collections: Biotechnology; Computer Technologies and Information Sciences