Summary: The EMBO Journal Vol.17 No.18 pp.5374­5387, 1998
Identification and analysis of PH domain-containing
targets of phosphatidylinositol 3-kinase using a
novel in vivo assay in yeast
Steven J.Isakoff, Tim Cardozo,
Julian Andreev, Zhai Li,
Kathryn M.Ferguson1, Ruben Abagyan,
Mark A.Lemmon1, Ami Aronheim2 and
Edward Y.Skolnik3
The Skirball Institute for Biomolecular Medicine and Department of
Pharmacology, New York University Medical Center, New York,
NY 10016, 1Department of Biochemistry and Biophysics, University
of Pennsylvania School of Medicine, Philadelphia, PA 19104-6089,
USA and 2Department of Medicine, Technion, Haifa, Israel
3Corresponding author
e-mail: Skolnik@saturn.med.nyu.edu
Phosphatidylinositol 3-kinase (PI3K) mediates a vari-
ety of cellular responses by generating PtdIns(3,4)P2
and PtdIns(3,4,5)P3. These 3-phosphoinositides then
function directly as second messengers to activate

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

Collections: Biology and Medicine