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INSTITUTE OF PHYSICS PUBLISHING PHYSICAL BIOLOGY Phys. Biol. 3 (2006) 183189 doi:10.1088/1478-3975/3/3/003
 

Summary: INSTITUTE OF PHYSICS PUBLISHING PHYSICAL BIOLOGY
Phys. Biol. 3 (2006) 183189 doi:10.1088/1478-3975/3/3/003
Optimal gene partition into operons
correlates with gene functional order
Alon Zaslaver, Avi Mayo, Michal Ronen and Uri Alon
Department of Molecular Cell Biology and Department of Physics of Complex Systems,
Weizmann Institute of Science, Rehovot 76100, Israel
E-mail: urialon@weizmann.ac.il
Received 26 April 2006
Accepted for publication 23 August 2006
Published 18 September 2006
Online at stacks.iop.org/PhysBio/3/183
Abstract
Gene arrangement into operons varies between bacterial species. Genes in a given system can
be on one operon in some organisms and on several operons in other organisms. Existing
theories explain why genes that work together should be on the same operon, since this allows
for advantageous lateral gene transfer and accurate stoichiometry. But what causes the
frequent separation into multiple operons of co-regulated genes that act together in a pathway?
Here we suggest that separation is due to benefits made possible by differential regulation of
each operon. We present a simple mathematical model for the optimal distribution of genes

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine