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JOURNAL OF NANOSCIENCEAND NANOTECHNOLOGY Scanning Probe Microscopy with Landmark
 

Summary: JOURNAL OF NANOSCIENCEAND NANOTECHNOLOGY
Scanning Probe Microscopy with Landmark
Referenced Control for Direct
Biological Investigations
B. GoolsbylaQ. Chen,a L. UdpalaY. Fan,aR. SamonalaB. Bhooravanla
F. M. SalamIaD. H. Wang,b and V. M. Ayresa
aDepartment of Electrical and ComputerEngineering, Michigan State University,East Lansing, Michigan 48824, USA
Departmentof Medicine, Michigan State University,East Lansing, Michigan 48824, USA
We report the successful use of continuouswavelet transforms applied to atomic force microscope
data sets for landmark recognition of biological features. The data sets were images of mixed red
and white blood cells. Contrast enhancement followed by continuous wavelet transform of the data
was used to successfully distinguish erythrocytes from neutrophil and monocyte leukocytes within
the mixed cell images.All of the above are sphericalobjects between 6 and 8 pm in diameter,which
demonstrates the ability to sort similar biological objects into distinct classes. The implications for
development of on-line scanning probe recognition microscopy are discussed.
Keywords: Scanning Probe Microscopy, Atomic Force Microscopy, Biological Systems, Cells,
Image Processing, Continuous Wavelet Transform.
1. INTRODUCTION
Scanning probe microscopy (SPM) provides high-
resolution imaging of specimens, including biological

  

Source: Ayres, Virginia - Department of Electrical and Computer Engineering, Michigan State University

 

Collections: Materials Science; Biology and Medicine