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Orexin/hypocretin is necessary for context-driven cocaine-seeking Rachel J. Smith, Pouya Tahsili-Fahadan, Gary Aston-Jones*
 

Summary: Orexin/hypocretin is necessary for context-driven cocaine-seeking
Rachel J. Smith, Pouya Tahsili-Fahadan, Gary Aston-Jones*
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave., 403 Basic Science Bldg., Charleston, SC 29425-5100, USA
a r t i c l e i n f o
Article history:
Received 22 May 2009
Accepted 29 June 2009
Keywords:
Self-administration
Reinstatement
Addiction
Abstinence
Orexin
Cocaine
a b s t r a c t
Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in addiction
and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated
context following abstinence or extinction from chronic cocaine self-administration. Male Sprague­
Dawley rats self-administered cocaine in 2-h sessions for 10 days, followed by extinction training or
extended abstinence in the home cage. The OX1R antagonist SB-334867 (SB; 10, 20, or 30 mg/kg, i.p.) was

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine