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18 VOLUME 15 NUMBER 1 JANUARY 2008 NATURE STRUCTURAL & MOLECULAR BIOLOGY Stuttering against marginotomy
 

Summary: 18 VOLUME 15 NUMBER 1 JANUARY 2008 NATURE STRUCTURAL & MOLECULAR BIOLOGY
Stuttering against marginotomy
Manuel Ares, Jr. & Kausik Chakrabarti
Stuttering by telomerase contributes to the natural heterogeneity of fission yeast telomeric repeat sequences.
In the early 1970s it was realized that
practically every bit of DNA synthesis of
any informational importance occurs in a
primer- and template-dependent fashion.
These requirements left the very ends of
any linear DNA without an obvious means
for replication. This became known to a
few as marginotomy1, a widely underused
word that defines the `end-replication
problem'. Now we know that evolution
has found numerous solutions to the end-
replication problem that serve linear DNA
molecules from tiny viral genomes to foot-
long eukaryotic chromosomes. A successful
solution is provided by the RNA-protein
enzyme telomerase. In this issue of Nature

  

Source: Ares Jr., Manny - Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz

 

Collections: Biology and Medicine