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www.landesbioscience.com Fly 1 Fly 4:3, 1-3; July/August/September 2010; 2010 Landes Bioscience
 

Summary: www.landesbioscience.com Fly 1
Fly 4:3, 1-3; July/August/September 2010; 2010 Landes Bioscience
BrieF CommuniCAtion BrieF CommuniCAtion
*Correspondence to: David N. Arnosti; Email: arnosti@msu.edu
Submitted: 03/19/10; Revised: 04/27/10; Accepted: 04/29/10
Previously published online: www.landesbioscience.com/journals/fly/article/12200
Introduction
In eukaryotes, DNA is packaged into chromatin, which imposes
a natural barrier for various DNA-related processes including
transcription and replication.1
Eukaryotic cells deploy multiple
mechanisms to alter the positions of nucleosomes in order to
enhance the accessibility of DNA.2
In the case of transcription,
regulatory factors recruit chromatin remodeling complexes such
as SWI/SNF and ISWI to remove, transfer or slide a nucleosome
along the DNA template.3
Alternatively, histone modifying
enzymes can also be recruited by transcription factors to acety-
late, methylate, phosphorylate, monoubiquitinate, sumoylate or

  

Source: Arnosti, David N. - Department of Biochemistry and Molecular Biology, Michigan State University

 

Collections: Biology and Medicine