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ORIGINAL ARTICLE Towards a Single-Sequence Neurologic Magnetic

Towards a Single-Sequence Neurologic Magnetic
Resonance Imaging Examination: Multiple-Contrast Images
From an IR TrueFISP Experiment
Vikas Gulani, PhD, MD,* Peter Schmitt, MS,* Mark A. Griswold, PhD,* Andrew G. Webb, PhD,*
and Peter M. Jakob, PhD*
Objective: The objective of this study was to reconstruct images
bearing multiple contrasts from a single sequence magnetic reso-
nance imaging (MRI) experiment.
Materials and Methods: Using a segmented IR-TrueFISP imaging
sequence, the signal recovery after inversion and /2 preparation
was sampled in 6 volunteers. These images were used to generate
T1, T2, and spin-density maps, allowing construction of images with
multiple contrasts, including T1-, T2-, spin-density-weighted, and
also FLAIR contrast. Traditionally acquired images bearing the
corresponding contrast were obtained for comparison. Regression
analysis was performed to compare the synthetic and traditionally
acquired images for the whole brain and a region of interest in the
occipital region.
Results: The synthetic images closely reproduced the contrast from


Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University


Collections: Biology and Medicine