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Differential utilization of T cell receptor TCR /TCR locus variable region gene segments is mediated
 

Summary: Differential utilization of T cell receptor TCR /TCR
locus variable region gene segments is mediated
by accessibility
Yu Nee Lee1
, Frederick W. Alt2
, Julia Reyes, Megan Gleason, Ali A. Zarrin, and David Jung1
Howard Hughes Medical Institute, Children's Hospital Boston, Immune Disease Institute, Harvard Medical School, Boston, MA 02115
Contributed by Frederick W. Alt, August 25, 2009 (sent for review August 3, 2009)
T cell receptor (TCR) variable region exons are assembled from
germline V, (D), and J gene segments, each of which is flanked by
recombination signal (RS) sequences that are composed of a
conserved heptamer, a spacer of 12 or 23 bp, and a characteristic
nonamer. V(D)J recombination only occurs between V, D, and J
segments flanked by RS sequences that contain, respectively,
12(12-RS)- and 23(23-RS)-bp spacers (12/23 rule). Additional mech-
anisms can restrict joining of 12/23 RS matched segments beyond
the 12/23 rule (B12/23). The TCR locus is contained within the
TCR locus; TCR variable region exons are encoded by TRAV and
TRAJ segments and those of TCR by TRDV, TRDD, and TRDJ
segments. On the basis of the 12/23 rule, both TRAV and TRDV gene

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine