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Clinical Science (2010) 118, 439450 (Printed in Great Britain) doi:10.1042/CS20090474 439 R E V I E W
 

Summary: Clinical Science (2010) 118, 439450 (Printed in Great Britain) doi:10.1042/CS20090474 439
R E V I E W
A new look at the pathogenesis of asthma
Stephen T. HOLGATE
, Hasan S. ARSHAD
, Graham C. ROBERTS
, Peter H.
HOWARTH
, Philipp THURNER and Donna E. DAVIES

Division of Infection, Inflammation and Immunity, University of Southampton, Southampton General Hospital, Southampton
SO16 6YD, U.K., and Bioengineering Sciences Research Group, University of Southampton, Southampton, SO17 1BJ, U.K.
A B S T R A C T
Asthma is an inflammatory disorder of the conducting airways that has strong association with
allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell
response, but in general targeting this component of the disease with selective therapies has been
disappointing and most therapy still relies on bronchodilators and corticosteroids rather than
treating underlying disease mechanisms. With the disappointing outcomes of targeting individual
Th-2 cytokines or manipulating T-cells, the time has come to re-evaluate the direction of research
in this disease. A case is made that asthma has its origins in the airways themselves involving

  

Source: Anderson, Jim - School of Mathematics, University of Southampton

 

Collections: Mathematics