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Summary: © 2005 Nature Publishing Group
RESEARCH PRIZE IN DEVELOPMENTAL BIOLOGY
E SSAY
Gene targeting in mice: functional
analysis of the mammalian genome
for the twenty-first century
Mario R. Capecchi
Abstract | Gene targeting in mouse
embryonic stem cells has become the `gold
standard' for determining gene function
in mammals. Since its inception, this
technology has revolutionized the study of
mammalian biology and human medicine.
Here I provide a personal account of the
work that led to the generation of gene
targeting which now lies at the centre of
functional genomic analysis.
Gene targeting -- creating designed genomic
modifications -- has three enormous
advantages relative to other procedures for
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