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Biochemical Basis of Respiratory Disease 873 Cytoplasmic tail of IL-13R2 regulates IL-4

Summary: Biochemical Basis of Respiratory Disease 873
Cytoplasmic tail of IL-13R2 regulates IL-4
signal transduction
Allison-Lynn Andrews*1
, Ida Karin Nordgren, Isabelle Kirby, John W. Holloway*, Stephen T. Holgate*,
Donna E. Davies* and Ali Tavassoli
*School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, U.K., and School of Chemistry,
Highfield Campus, University of Southampton, University Road, Southampton SO17 1BJ, U.K.
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4
and IL-13 share many functional properties as a result of their utilization of a common receptor complex
comprising IL-13R1 (IL-13 receptor -chain 1) and IL-4R. The second IL-13R (IL-13 receptor) has been
identified, namely IL-13R2. This has been thought to be a decoy receptor due to its short cytoplasmic tail
and its high binding affinity for IL-13 but not IL-4. IL-13R2 exists on the cell membrane, intracellularly and
in a soluble form. Recent reports revealed that membrane IL-13R2 may have some signalling capabilities,
and a soluble form of IL-13R2 can be generated in the presence of environmental allergens such as DerP.
Interestingly, IL-13R2 has also been shown to regulate both IL-13 and IL-4 response in primary airway cells,
despite the fact that IL-13R2 does not bind IL-4. The regulator mechanism is still unclear but the physical
association of IL-13R2 with IL-4R appears to be a key regulatory step. These results suggest that the
cytoplasmic tail of IL-13R2 may interfere with the association or activation of signalling molecules, such


Source: Anderson, Jim - School of Mathematics, University of Southampton


Collections: Mathematics