Summary: argument for delayed evaluation of combination therapy
because: (1) there are reports of high levels of CQ or
antifolate drug resistance [5]; and (2) urbanization, by
reducing overall parasite circulation, could permit
genetic drift, thus fixing resistant alleles among closed
populations in Africa (as has happened in Southeast
Asia and South America) [6]. We urgently need standar-
dized population-based longitudinal studies of P. falci-
parum drug resistance to implement accurate drug
policies in Africa.
References
1 Gueret, D. et al. (1992) Stabilite´ de la re´sistance a` la chloroquine de
P. falciparum entre 1987 et 1989 a` Mounana. Gabon. Bull. WHO 70,
621­624
2 Pradines, B. et al. (2001) Ferrocene-chloroquine analogues as anti-
malarial agents: in vitro activity of ferrochloroquine against 103
Gabonese isolates of Plasmodium falciparum. J. Antimicrob. Che-
mother. 48, 179­184
3 Pradines, B. et al. (1999) In vitro activities of benflumetol against 158
senegalese isolates of P. falciparum in comparison with those of

Source: Aksoy, Serap - School of Public Health, Yale University

Collections: Biology and Medicine